Study Objective: To establish a dose-response curve for the analgesic effect of intrathecal neostigmine in patients undergoing below knee surgery with spinal anesthesia. To assess adverse effects, principally nausea and vomiting.Design: Randomized, double-blind, prospective study.Setting: Teaching hospital.Patients: 60 ASA physical status I and II premedicated patients undergoing orthopedic surgery (tibial or ankle reconstruction).Interventions: Spinal anesthesia was performed at the sitting position, L 3-L 4 interspace, 4 ml final volume, injected at a rate of 1 ml/10 sec. The control group (CG) received 15 mg hyperbaric bupivacaine 0.5% plus saline. The 25 μg neostigmine group (25NG) received 15 mg hyperbaric bupivacaine plus 25 μg neostigmine; the 50 μg neostigmine group (50NG) received 15 mg hyperbaric bupivacaine plus 50 μg neostigmine; and the 100 μg neostigmine group (100NG) received 15 mg hyperbaric bupivacaine plus 100 μg neostigmine. Patients were placed supine after the spinal punction.Measurements and Main Results: Time to first rescue analgesics, analgesia, and adverse effects at constant intervals were assessed using the 10 cm visual analog scale (VAS).
Intrathecal neostigmine produced a dose-independent reduction in the postoperative rescue analgesic consumption ( p 0.05), and the overall 24-hour VAS pain scores were lowest for patients who had spinal neostigmine ( p.
Combined intrathecal fentanyl and neostigmine: Combined intrathecal fentanyl and neostigmine:Lauretti, Gabriela R; Mattos, Anita L; Reis, Marlene P; Pereira, Newton L1998-06-01 00:00:00Study Objective: To evaluate the analgesic action of spinal neostigmine as part of a multimodal analgesic therapy approach including spinal neostigmine and spinal fentanyl for postoperative pain relief. Design: Randomized, prospective study. Setting: Teaching hospital.
Patients: 50 ASA physical status I and II patients undergoing abdominal hysterectomy. Interventions: Patients were assigned to one of five groups (n = 10) to receive 15 mg bupivacaine plus 1 ml of the test drug intrathecally. The control group (CG) received saline as the test drug, the fentanyl group (FG) received 25 μg fentanyl; the neostigmine group (NG) received 25 μg neostigmine; the fentanyl-neostigmine 10 μg group (FNG10) was given 10 μg fentanyl plus 10 μg neostigmine; and the fentanyl-neostigmine 25 μg group (FNG25) received 25 μg fentanyl plus 25 μg neostigmine. Pain and nausea were evaluated using a 10-cm visual analog scale (VAS). Main Results: The analgesic consumption, in 24 hours was greatest in CG, next highest in NG, FG, and FNG10 where consumption was the same in the three groups; and least in FNG25 (p 5 hours compared with 2 to 3 hours; p 0.05). Legacy of kain defiance for pc with crack. Conclusion: The combination of 25 μg neostigmine with 25 μg fentanyl given intrathecally with 15 mg of hyperbaric bupivacaine delayed postoperative pain and lowered the number of rescue analgesics. Because the better quality of analgesia was obtained with an increased (although not statistically significant difference) incidence of untoward side effects, larger samples should be studied before its routine use is recommended.Journal of Clinical Anesthesia Elsevier http://www.deepdyve.com/lp/elsevier/combined-intrathecal-fentanyl-and-neostigmine-Te5tJJV0Jh.
AbstractStudy Objective: To evaluate the analgesic action of spinal neostigmine as part of a multimodal analgesic therapy approach including spinal neostigmine and spinal fentanyl for postoperative pain relief. Design: Randomized, prospective study.
Intrathecal Neostigmine Pdf File
Setting: Teaching hospital. Patients: 50 ASA physical status I and II patients undergoing abdominal hysterectomy.
Ho Kyung Song
Interventions: Patients were assigned to one of five groups (n = 10) to receive 15 mg bupivacaine plus 1 ml of the test drug intrathecally. The control group (CG) received saline as the test drug, the fentanyl group (FG) received 25 μg fentanyl; the neostigmine group (NG) received 25 μg neostigmine; the fentanyl-neostigmine 10 μg group (FNG10) was given 10 μg fentanyl plus 10 μg neostigmine; and the fentanyl-neostigmine 25 μg group (FNG25) received 25 μg fentanyl plus 25 μg neostigmine. Pain and nausea were evaluated using a 10-cm visual analog scale (VAS). Main Results: The analgesic consumption, in 24 hours was greatest in CG, next highest in NG, FG, and FNG10 where consumption was the same in the three groups; and least in FNG25 (p 5 hours compared with 2 to 3 hours; p 0.05). Conclusion: The combination of 25 μg neostigmine with 25 μg fentanyl given intrathecally with 15 mg of hyperbaric bupivacaine delayed postoperative pain and lowered the number of rescue analgesics.
Because the better quality of analgesia was obtained with an increased (although not statistically significant difference) incidence of untoward side effects, larger samples should be studied before its routine use is recommended.JournalJournal of Clinical Anesthesia– ElsevierPublished: Jun 1, 1998.